PremPDI - Predicts the Effects of Mutations on
PremPDI can be used to evaluate the effects of variations and disease mutations on protein-DNA interactions only for soluble complexes. It predicts if a mutation disrupts an interaction and calculates the change in binding affinity. The structure of a protein-DNA complex is required for this method.
Zhang N, Chen Y, Zhao F, Yang Q, Simonetti FL, Li M. PremPDI estimates and interprets the effects of missense mutations on protein-DNA interactions. PLoS Comput Biol 2018, 14(12):e1006615. PMID: 30533007
School of Biology & Basic Medical Sciences, Soochow University
199 Ren-Ai Road, Suzhou, Jiangsu, 215123 P.R. China