PremPDI - Predicts the Effects of Mutations on

Protein-DNA Interactions

PremPDI can be used to evaluate the effects of variations and disease mutations on protein-DNA interactions only for soluble complexes. It predicts if a mutation disrupts an interaction and calculates the change in binding affinity. The structure of a protein-DNA complex is required for this method.
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Reference

Zhang N, Chen Y, Zhao F, Yang Q, Simonetti FL, Li M. PremPDI estimates and interprets the effects of missense mutations on protein-DNA interactions. PLoS Comput Biol 2018, 14(12):e1006615. PMID: 30533007


School of Biology & Basic Medical Sciences, Soochow University
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