PremPRI predicts the effects of single muta-tions occurring in RNA binding proteins on the protein-RNA interactions by calculating the binding affinity changes quantitatively. It can be used for finding functionally importantvariants, understanding the molecular mechanisms, and designing new protein-RNA interaction inhibitors. The 3D structure of a protein-RNA complex is required forperforming the prediction.

Step1 - Select Protein-RNA Complex

Reference

Zhang N, Lu H, Chen Y, Zhu Z, Yang Q, Wang S, Li M. PremPRI: Predicting the Effects of Missense Mutations on Protein–RNA Interactions. Int. J. Mol. Sci. PMID: 32756481