PremPS evaluates the effects of single muta-tions on protein stability by calculating thechanges in unfolding Gibbs free energy. It canbe applied to a large number of tasks, in-cluding finding functionally important variants,understanding their molecular mechanismsand protein design. 3D structure of a proteinis required for this method.
Step1 - Select Protein
Reference
Chen Y, Lu H, Zhang N, Chen Y, Zhu Z, Wang S, Li M. PremPS: Predicting the impact of missense mutations on protein stability. PLoS Comput Biol
. PMID: 33378330
School of Biology & Basic Medical Sciences, Soochow University 199 Ren-Ai Road, Suzhou, Jiangsu, 215123 P.R. China