PremPS - Predicting the Effects of Mutations on

Protein Stability

PremPS evaluates the effects of single muta-tions on protein stability by calculating thechanges in unfolding Gibbs free energy. It canbe applied to a large number of tasks, in-cluding finding functionally important variants,understanding their molecular mechanismsand protein design. 3D structure of a proteinis required for this method.

Step1 - Select Protein

Example: 1YU5
       Asymmetric Unit


Chen Y, Lu H, Zhang N, Chen Y, Zhu Z, Wang S, Li M. PremPS: Predicting the impact of missense mutations on protein stability. PLoS Comput Biol . PMID: 33378330

School of Biology & Basic Medical Sciences, Soochow University
199 Ren-Ai Road, Suzhou, Jiangsu, 215123 P.R. China