PremPS - Predicting the Effects of Mutations on
PremPS evaluates the effects of single muta-tions on protein stability by calculating thechanges in unfolding Gibbs free energy. It canbe applied to a large number of tasks, in-cluding finding functionally important variants,understanding their molecular mechanismsand protein design. 3D structure of a proteinis required for this method.
Chen Y, Lu H, Zhang N, Chen Y, Zhu Z, Wang S, Li M. PremPS: Predicting the impact of missense mutations on protein stability. PLoS Comput Biol
. PMID: 33378330
School of Biology & Basic Medical Sciences, Soochow University
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